Aims to understand metabolic crosstalk between immune and melanoma cells at early stages of metastasis

Researches pediatric sarcomas driven by fusion oncogenes. Leads the development of novel approaches to phenotypic characterization of primary pediatric cancer cells in vivo

Develops the clearing and labeling strategies necessary to visualize early metastatic colonization events

Develops and applies light-sheet-based imaging techniques to live-cell and zebrafish embryo related studies

Develops light-sheet and multiphoton microscopes for rapid volumetric imaging with high resolution

Develops and applies automated multi-scale microscopy to investigate the dynamic processes of metastasis in zebrafish xenografts

Researches non-genomic mechanisms that promote plasticity in migration and proliferation/survival for cancer cells. Leads the development of high-throughput live cell imaging technologies

Researches and develops cutting-edge microscopy instrumentation and analysis. Leads the development of an automated, multi-scale, self-driving imaging system for early metastatic events

Develops computational models to understand cancer cell signaling in the 3D morphological context

Researches and develops transformative imaging technologies. Leads the development of novel imaging assays in Zebrafish xenografts to investigate metastasis mechanisms

Researches the pathogenic mechanisms of adult and pediatric cancers using cutting edge genomics, spatial and single cell -omics based technologies

Studies the morphological requirements for Ras oncogenic signaling

Applies light sheet microscopy and imaging techniques to detect earliest events of melanoma metastasis and study the mechanisms that determine melanoma cell fates at metastatic sites

Researches dysregulated cytoskeleton in cancer cell survival and metastasis

Studies altered mechanisms related to leukemia using zebrafish & other in vitro cancer models

Investigates the tumor microenvironment of Ewing sarcoma

Researches the mechanisms of pediatric sarcoma metastasis in the Zebrafish embryo

Builds light-sheet microscopes capable of imaging subcellular architectures deep within tissue contexts

Develops animal models to study Ewing sarcoma pathogenesis and experimental therapeutics

Studies how lipid metabolism regulates oxidative stress during cancer metastasis

Works on developing a high-throughput zebrafish imaging system based on oblique plane microscopy to analyze cancer metastatic niches in vivo

Studies formation of bone metastases and the effect of tumorigenesis on hematopoietic stem cells

Applies microscopy and imaging techniques developed by Dean and Fiolka to visualize earliest stages of melanoma metastasis for elucidation of mechanisms that determine melanoma cell fate

Studies the role of tumor microenvironment in tumor development, metastasis, and drug resistance by computational integration of high-dimensional datasets such as single-cell RNA/DNA sequencing and spatial omics

Studies mechanisms of therapy resistance in melanoma using highly multiplexed imaging, spatially-resolved transcriptomics, and genetically engineered tumor models

Develops assays for probing the mechanism of human cancer metastasis in zebrafish embryos

Investigates functions of the CAV-1 gene in enabling Ewing Sarcoma metastasis

Develops algorithms & methods to address specific goals in 3D image analysis

Quantitative analyses of cytoskeletal alterations in early metastatic colonizing cells

Studies signal transduction and oncogenic mechanisms in single cells using a combination of computational and experimental methods. In this Center, the Sorger Lab leads the acquisition and analysis of highly multiplexed, single-cell imaging and genomic data

Investigates the developmental origin of Ewing sarcoma using a novel zebrafish model and studies the role of proteoglycans in cancer cell transformation and tumor development

Develops autonomous microscope control software to automatically identify and interrogate rare biological phenomena

Studies the relationship between cell membrane changes and metastasis in Ewing sarcoma

Researches cellular blebbing as a morphologically encoded signaling hub, uncovering the molecular mechanisms behind this novel signaling axis and exploring its role in cancer cell survival and metastasis

Studies how heterogeneity among melanoma cells impact melanoma cell growth and the metastatic potential

Clarence has implemented deep learning image analysis methods for single cell quantification in thin tissue samples and is currently interested in applying novel 3D optical methods to characterize diseased tissue

Develops mathematical models of causality between cell morphology and signaling in metastatic cells