The Cancer Complexity Knowledge Portal presents datasets, publications, and other resources generated by NCI interdisciplinary research programs. Scientists across these programs integrate synergistic approaches, work on data, and develop tools in collaboration to address important questions in basic and translational cancer research. This repository encompasses not only CCBIR (our parent consortium) but all under NCI.
We produce custom software to run our custom microscopes. ASLM is an open source Python package for control of light-sheet microscopes. It allows for easily reconfigurable hardware setups and automated acquisition routines. - courtesy of Dean Lab
Publications
Blebs promote cell survival by assembling oncogenic signaling hubs
Andrew D. Weems, Erik S. Welf, Meghan K. Driscoll, Felix Y. Zhou, Hanieh Mazloom-Farsibaf, Bo-Jui Chang, Vasanth S. Murali, Gabriel M. Gihana, Byron G. Weiss, Joseph Chi, Divya Rajendran, Kevin M. Dean, Reto Fiolka & Gaudenz Danuser. Nature (2023) 615: 517–525.
Resolution doubling in light-sheet microscopy via oblique plane structured illumination
Bingying Chen, Bo Jui Chang, Philippe Roudot, Felix Zhou, Etai Sapoznik, Madeleine Marlar-Pavey, James B. Hayes, Peter T. Brown, Chih Wei Zeng, Talley Lambert, Jonathan R. Friedman, Chun Li Zhang, Dylan T. Burnette, Douglas P. Shepherd, Kevin M. Dean, and Reto P. Fiolka. Nature Methods (2022) 19: 1419–1426.
Increasing the field-of-view in oblique plane microscopy via optical tiling
Bingying Chen, Bo-Jui Chang, Felix Y. Zhou, Stephan Daetwyler, Etai Sapoznik, Benjamin A. Nanes, Isabella Terrazas, Gabriel Muhire Gihana, Lizbeth Perez Castro, Isaac S. Chan, Maralice Conacci-Sorrell, Kevin M. Dean, Alfred Millett-Sikking, Andrew G. York, and Reto Fiolka. Biomedical optics express (2022) 13 (11): 5616–5627.
In vivo 3D profiling of site-specific human cancer cell morphotypes in zebrafish
Dagan Segal, Hanieh Mazloom-Farsibaf, Bo-Jui Chang, Philippe Roudot, Divya Rajendran, Stephan Daetwyler, Reto Fiolka, Mikako Warren, James F. Amatruda, and Gaudenz Danuser.
J Cell Biol (2022) 221 (11): e202109100.